Description
GHK-Cu (glycine-histidine-lysine) is a tripeptide that binds copper ions and acts as a master regulator of tissue repair. It activates TGF-β and increases collagen I, III, and IV synthesis while simultaneously upregulating matrix metalloproteinases to clear damaged collagen — a repair-and-rebuild cycle your skin runs continuously when GHK-Cu is present. It also stimulates nerve growth factor (NGF), making it one of the few peptides with both structural and neurological skin benefits.
Female skin is estrogenic — meaning estrogen receptors in keratinocytes and fibroblasts directly influence how well your skin synthesizes collagen and retains moisture. As estrogen declines (starting in your early 30s, accelerating in perimenopause), GHK-Cu levels fall in parallel. Supplementing GHK-Cu re-engages these repair pathways independent of estrogen, making it effective across all hormonal phases. Research in women specifically shows measurable improvement in skin laxity, fine line depth, and hair follicle density over 8–12 weeks.
Female-calibrated dosing: 0.5–1mg subcutaneously 3–5x per week. The 100mg vial supports an extended 12–16 week protocol or dual-route use (injectable + topical). For topical application, reconstitute in bacteriostatic water and apply 1–2x daily. Cycle phase timing: no contraindications — can be used continuously.
Storage: Store lyophilized powder below -20°C. After reconstitution, refrigerate at 2–8°C and use within 30 days. Protect from light.






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